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In the pituitary gland, it co-localizes with numerous peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotropic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH), and melanin-concentrating hormone (MCH)

Real-world data suggest many patients adapt by week 46 with supportive care

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