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Despite being derived from -MSH, KPV's anti-inflammatory effects appear to operate independently of the melanocortin receptor system

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This gives Mounjaro a slight advantage in achieving faster weight-loss results. In a head-to-head clinical trial, Lilly reported that tirzepatide led to an average weight reduction of 20.2%, compared to 13.7% with semaglutide after 72 weeks of treatmenta 47% greater relative weight loss with tirzepatide