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Ideal for Malabsorption Issues : People with conditions such as pernicious anemia, celiac disease, Crohns disease, or those who have had weight loss surgery may struggle to absorb B12 through the gut

This supports a model in which CHAC1-mediated GSH depletion destabilizes NRF2 and reduces cystine import, allowing iron-dependent lipid peroxides to accumulate and trigger ferroptosis

However, standard oral supplements face a significant hurdle: the digestive system

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Cysteine is frequently identified as rate-limiting, or limiting the ability of glutathione synthesis based on lack of availability