SUSTAIN-6 (semaglutide) [53], PIONEER 6 (semaglutide) [61], and LEADER (liraglutide) [54] looked at similar patient populations (over 50 years old with established cardiovascular disease) and found that GLP-1RAs produce a cardiovascular protective function relative to primary endpoints (Table 1)

That fundamental research research like the kind Richard DiMarchi conducts has to come from laboratories at universities, smaller companies and startups. When the chemistry department recruited DiMarchi, he insisted his lab be in Bloomington, even though it initially required travel from his primary residence in Carmel, Indiana, because at the core I am a chemist, and the chemistry department at Indiana University Bloomington is world-class. Clemmer, who was chair of the department when DiMarchi joined, said he was able to recruit DiMarchi because of the opportunity to collaborate with the departments visionary researchers and access other leading academic researchers like German physician Matthias Tschp, a key player in the refinement of GLP-1 drugs for obesity treatment
Oral GLP-1 medications overcame this hurdle by pairing semaglutide with SNAC, an absorption-enhancing compound
There are no validated outcome measures of RBC efficacy that assess tissue oxygenation function
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