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J Autism Dev Disord 2009;39:544-6

Joint discomfort, gut issues, and slow recovery from exercise are common barriers that can stall progress

doi: 10.1111/jpi.12138 127 OhashiTAkazawaTAokiMKuzeBMizutaKItoYet al

Key research themes involving glutathione include: Scavenging of free radicals (e.g., peroxides, nitrogen dioxide, hypochlorous acid) Support of other antioxidant systems (e.g., vitamin C and vitamin E recycling) Detoxification via glutathione S-transferases and related enzymes Regulation of protein folding, disulfide-bond formation, and thiol redox status Modulation of inflammatory mediators, nitric oxide pathways, and cellular metabolism Because endogenous glutathione synthesis capacity appears to decrease with age in many models, glutathione is frequently used as both an experimental variable and a biomarker in studies of aging, disease susceptibility, and redox imbalance

4 Immunometabolism as the link between steroid hormones and inflammation and immunity 4.1 Glucocorticoids As discussed, glucocorticoid receptor signaling promotes anti-inflammatory and immunosuppressive activities of innate immune cells, including macrophages and myeloid-derived suppressor cells