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Potential for metabolic overstimulation: Chronic AMPK activation beyond physiological norms could theoretically disrupt normal energy signaling
Just how much of a challenge this posed can be gauged from the fact that Mutt's group needed 10km of porcine small intestine to obtain about 1mg of pure secretin (Rehfeld 2012)
Increased flux in TCA cycle in the mitochondria enhances production of reductive equivalents and flux of the electrons in the electron transport chain (ETC)
Pigmentation isnt always just about whats already on your skin
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