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A side effect of this reaction is that intracellular NAD + levels increase.[7,8] Upregulation of the pathway that induces NQO1 occurs in calorie restriction and appears to be an important component of producing the benefits.[9,10] Cells maintain much higher amounts of the NAD molecule as NAD + , with an estimated 90% of NAD content in uncomplexed proteins being as oxidized NAD + .[11,12] The reason cellular NAD + is maintained at such a high ratio is thought to be because of its role in several epigenetic transcriptional processes (i.e., processes that regulate how genes respond to the environment)
[5] Once in circulation, a portion of the free testosterone is converted to dihydrotestosterone (DHT) by 5-reductase in certain tissues, and both testosterone and DHT bind to intracellular androgen receptors
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The reduced form is also referred to as L-glutathione
