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In an oxaliplatin-resistant model of colon cancer, erianin downregulates the expression of drug efflux protein P-glycoprotein (P-gp) by specifically inhibiting the JAK2/STAT3 signaling pathway, thereby effectively reversing the MDR phenotype of cancer cells (108)
Chronic use of these medications without concurrent glutathione support may contribute to long-term oxidative stress accumulation and cellular dysfunction
The double-blinded, randomized study compared oral semaglutide with placebo as an adjunct to the standard of care for MACE
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