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GLP-1 supplements promise to curb cravings and promote weight loss

Body weight changes came from metabolic shifts rather than illness or reduced eating

35 Without this stimulus, especially during a calorie deficit potentially exacerbated by GLP-1 effects, the body may be less efficient at utilizing dietary protein for muscle maintenance, leading to greater lean mass loss

Preclinical and clinical studies suggest that GLP-1RAs may reduce EAT volume/thickness, potentially exceeding overall weight loss, attenuate EAT inflammation and fibrosis, improve cardiomyocyte calcium handling, mitigate oxidative stress, and suppress pulmonary vein ectopy, thereby potentially reducing AF susceptibility and recurrence post-ablation

In addition, transcriptional shifts may not map linearly to protein-level or tissue-level behavior