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DSIP appears to help break this cycle through multiple mechanisms

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BPC-157 acts via the NO system, EGF/VEGF, gastroprotection, and neuroprotection

As a fatty acid amide, PEA interacts with the peroxisome proliferator-activated receptor alpha (PPAR-$\alpha$) and G-protein coupled receptors to down-regulate mast cell activation, offering an advanced model for studying the mitigation of visceral pain and chronic neuro-inflammatory signaling along the enteric nervous system

Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters