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If these intermediates build up faster than the Krebs cycle can process them, they become highly toxic, effectively choking the mitochondria and halting the entire energy-producing apparatus

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It should be noted that although ROS play a central role in regulating oxygen homeostasis [537, 538], it was traditionally considered as harmful byproducts of aerobic metabolism but not key signaling molecules that regulate cellular processes until recent years [538, 539]