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In addition, incretin enthusiasts had suffered a serious disappointment, when it was observed, at about the same time, that GIP although being potently insulinotropic in healthy individuals was ineffective in patients with type 2 diabetes ( not including secretin) also was a potent inhibitor of glucagon secretion ( Inspired by the similarity of GLP-1 with glucagon and oxyntomodulin, it was relevant to look at other glucagon-like gastro-intestinal actions of GLP-1, and via extensive human studies it was soon established that GLP-1 was a physiological and powerful inhibitor of gastrointestinal secretion (both gastric and pancreatic) and motility ( In spite of the disappointment with GIP in T2DM, it was time to see whether the new incretin would have any effects in T2DM patients

DOI: 10.1038/srep31788 [Google Scholar] Wu YC, Wang WT, Lee SS, Kuo YR, Wang YC, Yen SJ, et al

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Major advances in the understanding of the structure of class B GPCRs have recently been made, including for the GLP-1R 63,64