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Contact your GP immediately, call NHS 111, or attend A&E if you develop: Irregular heartbeat or palpitations that persist Chest pain or pressure Severe breathlessness Significant leg swelling These symptoms require assessment to determine their cause, which may or may not be related to your B12 treatment

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The impact of weight loss on fat-free mass, muscle, bone and hematopoiesis health: Implications for emerging pharmacotherapies aiming at fat reduction and lean mass preservation

What is consistent is the message for patients: these are effective medications with substantial benefits, and the sensible course is informed monitoring rather than avoidance