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ZhangWRefaatALiHZhuDTongZNicolazzoJAet alOptimizing angiopep-2 density on polymeric nanoparticles for enhanced bloodbrain barrier penetration and glioblastoma targeting: insights from in vitro and in vivo experiments

Unlike native IGF-1, which is rapidly bound and regulated by IGFBPs in circulation, IGF-1 LR3 was engineered to remain active longer, making it a useful tool for researchers studying sustained IGF-1 receptor signaling rather than the brief signaling windows native IGF-1 typically produces

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When used appropriately, peptides are generally well tolerated for many patients, though most are not FDA approved