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However, SGLT2 inhibitors could lead to a substantial increase in endogenous (hepatic) glucose production (EGP, HGP) and was accompanied by an increase in FPG concentration [12]

The same gastrointestinal side effects, central adaptations, and pleiotropic actions that once discouraged development are now recognized as manageable features of peptide pharmacology when appropriately contextualized

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Much of this early weight loss is actually water weight, not fat, as your body uses up stored glycogen (a carbohydrate reserve in your muscles and liver) that holds onto water