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It has been demonstrated that the recruitment of ARL8 to the surface of lysosomes and lysosome-related organelles is promoted by the evolutionarily conserved multisubunit BLOC-one-related complex (BORC) 26,27 , but the underlying mechanism remains uncertain

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The TIR domain-containing adapters include five proteins: MYD88, TIR domain-containing adapter inducing IFN- (TRIF, also termed TICAM1), TIR domain-containing adapter protein (TIRAP, also known as Mal), TIR domain-containing adaptor molecule 2 (TICAM2, also known as TRIF-related adapter molecule [TRAM]), and sterile alpha and TIR motif containing protein (SARM, also known as sterile alpha and armadillo motif containing protein)

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