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107 GLP-1s ability to mediate the incretin effect is its most studied and significant physiological effect due to the use of GLP-1 analogues (exenatide and liraglutide, lixisenatide, dulaglutide, albiglutide and semaglutide) in T2D treatment
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Despite that low penetrance, partial deficiency of CCT in B cells resulted in decreased peritoneal and splenic B cell numbers, inducing a compromised proliferation, especially in the periphery, decreasing serum IgG concentration, and increasing the incidence of IgM-secreting cells (107)
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