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In a recent meta-analysis of 12 observational studies of patients with T2DM treated with either SGLT2 inhibitors or GLP-1RAs, the GLP-1RA group exhibited a significantly lower relative risk of lower limb amputation vs the SGLT2 inhibitor cohort (3.54 vs 4.72 events per 1000 patient-years).37 Furthermore, in the CANVAS program involving 10,142 patients with T2DM at high cardiovascular risk, canagliflozin was found to be associated with a 1.97-fold increased risk of lower-limb amputations

Some countries treat it as an unregulated research compound

This matters because choosing a GLP-1 based only on brand reputation or lowest advertised side-effect rates misses crucial individual factors

Costs Considerations The cost of treatment can be a deciding factor for many patients: AOD 9604 : As a relatively newer option, AOD 9604 is often less expensive than Semaglutide

Download our guide to Managing GLP-1 Costs and Supporting Optimal Health Outcomes for ideas on how to start building your own strategy now