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In addition, most research is limited to short-term or subchronic periods (days to weeks), which are insufficient for assessing tolerance or delayed adverse effects

doi:10.1016/j.bbi.2011.07.229 Jahangard L, Sadeghi A, Ahmadpanah M, et al

Case of the Month Folic Acid Reduces Homocysteine in Older Adults Alzheimers Disease Linked to Saturated Fats by Archives of Neurology Download May 2003 Vol 17 No 5 Lead Article: "To Atkins or Not to Atkins" by Ron Hunninghake, M.D

Factors associated with impaired cerebrovascular reactivity and neurovascular coupling include cerebral microvascular dysfunction, insulin-like growth factor 1 (IGF-1) deficiency, and oxidative stress-related inhibition of neuronal and astrocytic vasodilators (Phillips et al., 2016