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Generally, GLP-1 drugs are available in pill or injection form, but some people have trouble with these formats

Starting at a higher dose would likely result in more side effects

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An open-label introductory period of the first 36 weeks, during which all subjects were treated with tirzepatide, followed by a 52-week double-blind treatment period, during which subjects were randomly assigned to receive either tirzepatide or placebo

Figure 2: Around half of GLP-1 side effects are gastrointestinal GLP-1s have previously been suggested to be linked to self-harm and suicidal thoughts, but the MHRA concluded in September 2024 that the available data do not support a causal association between GLP-1s and depression, suicidal ideation and suicide, following a review by the European Medicines Agencys pharmacovigilance risk assessment committee 24