Press release, 11 December 2025
An earlier trial in The New England Journal of Medicine found similar effects: Folks lost an average of 14.9 percent of their starting body weight with semaglutide over 68 weeks (7)
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Individual responses and risks can vary, and only a licensed healthcare professional can evaluate appropriateness, safety, contraindications, interactions, and monitoring needs in any therapeutic setting
Some patients feel differences within the first few weeks, though more noticeable weight loss typically happens once youve moved up to higher doses