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SLC7A11 inhibition results in GSH depletion, which downregulates GPX4 levels, thereby promoting cellular/subcellular membrane damage caused by LPOs [28]

Cassuto, J., & Sinclair, R

Table of Contents Toggle Literature Scope and Evidence Hierarchy This article is an evidence-informed narrative review rather than a systematic review or meta-analysis

Longevity protocol: Dose: 0.5-1mg daily (lower end) Frequency: 3-5 times weekly Cycle: 8 weeks on, 4 weeks off, indefinite repetition Combine with: Overall health optimization (sleep, nutrition, exercise) Lower doses for longevity reduce cost and theoretical concerns about long-term copper peptide use while potentially maintaining meaningful benefits

doi: 10.1016/j.phytochem.2022.113459 29 SilbersteinTHar-VardiIHarlevAFrigerMHamouBBaracTet al