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Graphical Abstract Similar content being viewed by others Introduction Osteoporosis is a common metabolic skeletal disease characterized by low bone mineral density and degeneration of bone tissue microarchitecture that affects specific categories of people, especially the elderly and postmenopausal women (Xu et al

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Its structure incorporates a C20 fatty diacid moiety that enables binding to serum albumin, extending its pharmacokinetic half-life and allowing for once-weekly administration in research protocols

Last, following combined treatment, osteogenesis-related biomarkers such as ALP, PINP, OPG, OCN and RUNX2 were markedly elevated, while bone resorption-related markers, including CTX-1, TRAP and RANKL, were markedly decreased (42), further confirming the osteogenic and anti-osteoporotic effects of ASD and Semaglutide

May 11, 2023