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In DR, high glucose inhibits Nrf2 activity by activating protein kinase C (PKC) and accumulating advanced glycation end products (AGEs), reducing retinal cell GSH/GPx4 levels, impairing iron export, inducing free iron and LPO accumulation, and activating ferroptosis in Mller, ARPE and endothelial cells, exacerbating vascular leakage (134136)
En pacientes ambulatorios con sndrome de hipoventilacin por obesidad, la ventilacin no invasiva autoajustada mostr una efectividad a largo plazo no inferior a la VNI ajustada manualmente, siendo adems ms coste-efectiva, expone la Dra
total sleep time = total time the child actually slept
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It involves weekly injections for one month
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