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After the first-month introductory price ($179 for semaglutide injections), ongoing costs are $299/month for compounded semaglutide injections, $349-$369 for semaglutide tablets, and $399/month for any tirzepatide option

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Some researchers theorize that the GIP component may actually help moderate some of the harsher GI effects of GLP-1 activation, which could partially explain why retatrutide compared to other agents does not always show proportionally worse GI profiles despite having three active mechanisms

The relative gene expression was determined using the 2 Ct method 14

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