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A 68-week randomised controlled trial of semaglutide in adults with overweight or obesity (without diabetes) found that while approximately 39% of the total weight lost was lean mass, this was within an acceptable clinical range and mostly proportional to the degree of total weight loss [4]
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Louie T, Golan Y, Khanna S, Bobilev D, Erpelding N, Fratazzi C, et al
Triple Hormone Receptor Agonist Retatrutide for Metabolic Dysfunction-Associated Steatotic Liver Disease: A Randomized Phase 2a Trial
