A2E Lipofuscin, a pyridinium bisretinoid, absorbs blue light and creates singlet oxygen upon excitation, leading to potential harm to retinal pigment epithelial cells or epoxidation of A2E
GLP-1 receptor agonists improve MASH mostly via extrahepatic actions: 1 CNS appetite control weight loss systemic inflammation 2 Chylomicron synthesis & improve lipid metabolism 3 Bind gut immune cells anti-inflammatory + microbiome benefits 4 Reduce adipose & pancreatic inflammation SUMMARY: Semaglutide & Tirzepatide works primarily by making you sick
Clinically 1 , IGF-1 signalling activates Akt/mTOR, the central switch for translating exercise and nutrition into muscle protein accretion and performance gains
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Because these drugs slow stomach emptying, they can affect how other oral medications are absorbed so timing may need adjusting for medications that depend on precise absorption, such as: Thyroid hormones Blood thinners Antibiotics with specific dosing schedules Certain pain medications Existing conditions matter too: a history of pancreatitis, gastroparesis, or certain thyroid conditions may make GLP-1 therapy inappropriate