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GLP-1RAs The natural ligand, GLP-1, is a 30-amino-acid incretin peptide secreted by intestinal L cells, effectively stimulating glucose-dependent insulin secretion, inhibiting glucagon release, slowing gastric emptying, and promoting satiety [62,63,64]

There is an immense effort to reveal the underlying causes of TDP-43 pathology and the downstream cellular events that are perturbed in diseased neurons

It adds that headaches persisting past that adjustment window merit a conversation with a provider to rule out other causes

[Laughs.] So, you know, as long as you have these drugs hitting those receptors youre gonna have those gastrointestinal side effects