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Myometrial contractions can result in spiral artery vasoconstriction and epithelial ischemia due to PGF2, which is generated by cyclooxygenase (COX-2)
doi: 10.1016/j.jacbts.2018.09.004 195 Ben-ShlomoSZvibelIShnellMShlomaiAChepurkoEHalpernZet al
Substantial metabolic effects
Hair loss is not listed as a documented side effect in FDA-approved clinical trials
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