Patients with a history of gastrointestinal conditions such as acid reflux, irritable bowel syndrome, or gastroparesis should be especially cautious when starting GLP-1 medications
Weeks 12: 2 mg once weekly Weeks 34: 4 mg once weekly Weeks 58: 8 mg once weekly Week 9+: 12 mg once weekly Efficacy and safety: The reason for the slow and gradual dosing protocol The Phase 2 clinical trial of retatrutide demonstrated that participants receiving the highest dose (12 mg) achieved up to 24% weight reduction after 48 weeks
Nausea decreased with duration of therapy and was reduced with dose titration (94)
Patients can sign-up to receive automated email alerts for when a GLP-1 drug is reported in supply in their area, or when the status of a GLP-1 drug on the FDAs Drug Shortage List changes
Incretin mimetics have demonstrated safety and efficacy in advanced kidney disease, however multiple studies have shown that use of GLP1-RA have shown improvements in glycemic control, body weight reductions, improved beta cell function, and decreased incidence hypoglycemia as compared to DPP4i in a general diabetes population 26,27,28,29,30,31 , effects which might explain the reduction of acute healthcare utilization observed in this study of patients with CKD treated with GLP1-RA as compared to DPP4i