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In acute inflammation models, E2 appears to enhance TLR-mediated pro-inflammatory responses in human and murine macrophages while also promoting T2 and anti-inflammatory activity in allergic asthma and cutaneous wound healing (110, 115, 150157)
Many patients and doctors consider it a starting point when newer agents are unavailable or too expensive
Supplementation may restore youthful sleep architecture more effectively in this population
Journal of Orthopaedic Research, 21(4), 753-758
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