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While other reviews have described the MACE risk reduction in the general population with T2DM [23, 24], non-T2DM [25], or both [26], the present study seeks to address the gap in the literature in providing a comprehensive meta-analysis on the number need to treat (NNT), efficacy and safety profile of GLP-1RA in reducing the risk of myocardial infarction (MI) and individual ASCVD constituents, namely non-fatal MI, unstable angina, coronary revascularization, and/or cardiovascular mortality
However, it does have a TGA indication for reducing the risk of kidney function decline in patients with type 2 diabetes and CKD
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Variants in the other peptide-pathway genes may influence how your body responds to GLP-1 medications during both steady-state and acute illness
