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Disclosures The LEADER, SUSTAIN-6, REWIND, PIONEER 6, SELECT, SOUL, STEP-HFpEF (with and without diabetes), and FLOW trials were sponsored by Novo Nordisk

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Dietary: Inadequate fiber or water intake can cause constipation, as can overconsumption of certain beverages, such as coffee, caffeinated tea, or alcohol

In the STEP-HFpEF trial, treatment with 2.4 mg of the glucagon-like peptide-1 receptor agonist semaglutide weekly produced substantial improvements in symptoms, physical limitations and exercise function and reduced inflammation and resulted in greater weight loss compared to placebo 11,12

See the Full Cost Breakdown Related Treatments Tirzepatide Therapy Dual GLP-1/GIP receptor agonist with up to 22.5% average weight loss in clinical trials