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The United States National Health and Nutrition Examination Survey 20112020

The cardiovascular outcomes suggest that GLP-1 therapy offers systemic health benefits beyond simple calorie restriction, making these medications attractive for overall metabolic health even in the absence of diabetes

Semaglutide is a synthetic 31-amino-acid polypeptide analog of the endogenous glucagon-like peptide-1 (GLP-1), belonging to the class of drugs labeled glucagon-like peptide-1 receptor agonists (GLP-1 RAs)

Persistent vomiting or an inability to keep fluids down, or signs of dehydration such as dizziness, dark urine, or markedly reduced urination

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