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L-carnitine used to treat hyper-ammonia in children with urea-cycle enzyme deficiencies26 and valproate-induced hyper-ammonia.27 The protec tive effects of L-carnitine are centrally mediated by activation of metabotropic Glu receptors at the level of brain ammonia uptake and/or mitochondrial energy metabolism
In addition, carnitine supplementation increased contracture of the heart shortly after reperfusion
Understanding the molecular structures of these drugs, their half-lives, dosing frequencies, and side effects is crucial for us to make informed decisions about which treatment would be most effective for each patient
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