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A major phase 3 trial suggests retatrutide may outperform current blockbuster weight loss drugs, with people on the highest dose losing more than 28% of body weight over 80 weeks

But it cannot override all of them indefinitely

Through various pathways, SIN suppresses the M1 polarization in macrophages, leading to a decrease in the production and secretion of diverse chemokines and pro-inflammatory cytokines, including TNF- and IL-8 (89, 104)