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Similar findings were identified in comparison with metformin (HR, 0.75
Hwaung P, Bosy-Westphal A, Muller MJ, Geisler C, Heo M, Thomas DM, Kennedy S, Heymsfield SB
Significantly decreased insulin and insulin receptor expression was observed in postmortem AD brain tissue, and changes in downstream insulin signaling molecules, including decreased levels of IRS-1/2, PI3K, p-Akt (51, 54)
However, long-term data on maintenance without continued cycling remains limited, and individual responses vary
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