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Gender-related different effects of a combined therapy of exenatide and metformin on overweight or obesity patients with type 2 diabetes mellitus
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Despite the guideline-recommended use of both SGLT2i and GLP-1RA therapy, there is a paucity of real-world evidence on the long-term effects of combining SGLT2is with newer generation GLP-1RAs (including once-weekly GLP-1RAs, once-daily oral semaglutide, and dual GLP-1/glucose-dependent insulinotropic polypeptide [GIP] agonists) on metabolic outcomes and other cardiorenal outcomes [22]
For people with diabetes, there is a potential risk of diabetic retinopathy complications, particularly if there is rapid improvement in glucose control
