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NICE guidelines recommend evidence-based weight management through dietary modification (600 kcal/day deficit), 150300 minutes weekly moderate-intensity physical activity, and behavioural change strategies

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Sensitivity analyses including MR Egger regression, weighted median, weighted mode (both weighted and simple), maximum likelihood, and RAPS yielded consistent results, thereby reinforcing our causal inferences

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[12] [1] Animal studies have shown an increased incidence of thyroid C-cell tumours with GLP-1 receptor agonists, although the relevance to humans is unknown