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Free Radical Biology and Medicine, 2004

Endocrine 64 (2), 349366

Tesamorelin is an FDA-approved synthetic growth hormonereleasing hormone analogue that stimulates IGF-1 production to reduce visceral abdominal fat in HIV-associated lipodystrophy, though its use outside this population remains unproven

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Factors to Weight Loss Resistance Several factors contribute to weight loss resistance, including thyroid and sex hormone imbalances, lack of exercise, chronic sleep deprivation, metabolic slowdown from chronic dieting, food allergies, gut dysbiosis, high cortisol levels due to chronic stress, insulin resistance, and exposure to environmental toxins