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Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, et al

Reticulocytosis (increased production of immature red blood cells) typically begins by day 3-4 of starting treatment, indicating active bone marrow recovery

Vitamin B12 (cobalamin) injections are a form of intramuscular or subcutaneous therapy used to treat vitamin B12 deficiency

Despite these points, for studies where efficacy and precise control are paramount, the benefits often outweigh the logistical hurdles