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Mediation analysis indicated that weight loss did not attenuate the treatment effect on MACE, while changes in waist circumference accounted for approximately one-third of the cardiovascular benefit

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In the protein digestion and absorption pathway, we observed that in the HFD group, the levels of several amino acids, including L-serine, proline, L-isoleucine, L-histidine, and L-glutamic acid, were significantly downregulated (Fig

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