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Native GLP-1 has been infused by the subcutaneous route (4.8 pmol/kg/min) using a portable insulin pump in a non-randomized study of subjects with type 2 diabetes over the age of 40 (mean age 55) with mean initial HbA1c of about 9%, and mean fasting glucose ~14 mM
Oral Semaglutide and Cardiovascular Outcomes in High-Risk Type 2 Diabetes
Direct neurotoxicity (unlikely but not ruled out)
Pregnancy/Breastfeeding: Discuss plans for pregnancy or if you're breastfeeding
For IBS, leaky gut, or inflammatory bowel conditions, the oral or sublingual troche is the first-choice route
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