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Second, the doses are small because the target is a high-affinity intracellular enzyme, not a receptor that needs saturating with milligrams of drug
10.1161/JAHA.120.018633 Summary Keywords intracranial aneurysm, DNA methylation, mRNA expression, 5-aza-2'-deoxycytidine, glutathione S-tranferase alpha 4 Citation Xu T, Yu X, Zhou S, Wu Y, Deng X, Wu Y, Wang S, Gao X, Nie S, Zhou C, Sun J and Huang Y (2023) DNA methylation and mRNA expression of glutathione S-transferase alpha 4 are associated with intracranial aneurysms in a gender-dependent manner
Changes in this receptor are linked to some types of type 2 diabetes
Exclusion criteria included a history of bariatric surgery, fundoplication, celiac disease, inflammatory bowel disease or GI cancers as well as a history of GP prior to GLP-1RA prescription
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