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Preclinical toxicology studies have not identified acute toxicity at doses far exceeding the effective range
Indeed, in the cardiovascular outcome trial (CVOT) for semaglutide, SUSTAIN 6 a relatively short (two-year) and small (3,297 individuals) preregistration trial (an extensive CVOT in obese individuals without T2DM (SELECT) is expected to complete in 2024) HbA 1c was powerfully and durably reduced
Liquid calories
Calorie restriction alone doesn't fix the signalling problem
Its high molecular weight and hydrophilicity support the need for coldchain storage
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