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Postmortem analysis has revealed that insulin resistance (IR) also occur in AD patients brain with significantly decreased expression of the insulin receptor, concomitant with the disease progression (66, 67) and indicated that the defects in insulin signaling are associated with AD pathogenesis (68)

These findings are open to criticism in that, by ignoring the possible genetic effects on UA transport into and within the brain, the approach used violates a central assumption of such studies

On the other hand, peripheral serotonin, once believed to mainly regulate intestinal mobility, is now understood to play key roles in regulating peripheral energy metabolism (812)

Martnez, Y