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The following information is provided for context only and reflects the inclusion criteria used in the 2023 Phase 2 clinical trial (Jastreboff et al., NEJM 2023) these are study-specific criteria and do not represent current UK prescribing standards or predict future NICE commissioning decisions

Altogether these results suggest that elevated oxidant stress promotes redirection of fluxes to the PPP, especially at +4 C, a phenomenon reversed by supercooled storage in E-Sol5 but not SAGM

However, at the time, some clinicians and compounding pharmacies argued the agency overstepped

"When people give it the backlash that it does get, I think it's kind of terrible

However, binding and enzyme inhibition studies revealed a 100-fold more potent affinity for GSTO1 than PDI