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Kobayashi A, Kang M-I, Okawa H, Ohtsuji M, Zenke Y, Chiba T, et al

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Glutathione is a tripeptide containing -amide bonds and sulfhydryl groups

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MC1R binding on melanocytes activates adenylyl cyclase via Gs, raising intracellular cAMP which activates protein kinase A (PKA)