Improved insulin sensitivity lowers hyperinsulinemia-induced ovarian androgen production, which is a central driver of menstrual irregularity in many with PCOS
Finally, vitamin B12 is crucial for the biochemistry of the nervous system, participating in DNA synthesis, methionine synthesis, methylation reactions, myelin synthesis, and neurotransmitter production (20, 25, 27, 42, 70, 73, 77)
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Additionally, combined with metformin, medication such as Topiramate, Zonisamide, and Valproic Acid may increase the risk of lactic acidosis
Hes since spent 20 years helping patients change their weight