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In both conformations, the pinane ring of the compound interacts with F324, V469, T471, A481 and L484 in subpocket C (Supplementary Fig
Ethics declarations Conflict of interest The authors declare that there exists no competing financial interest or personal relationships that could have appeared to influence the work reported in this paper
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Many compounds fit imperfectly and turn several locks at once
Altered downstream signaling by the IR with the L973F substitution is certainly in large part mediated by the decrease in IRS-1 binding/phosphorylation and increase in Shc binding/phosphorylation, as shown in this study
